Toward resourcefulness: pathways for community positive health

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Puppeteering as a metaphor for unpacking power in participatory action research on climate change and health

The health impacts of climate change are distributed inequitably, with marginalized communities typically facing the direst consequences. However, the concerns of the marginalized remain comparatively invisible in research, policy and practice. Participatory action research (PAR) has the potential to centre these concerns, but due to unequal power relations among research participants, the approaches often fall short of their emancipatory ideals. To unpack how power influences the dynamics of representation in PAR, this paper presents an analytical framework using the metaphor of ‘puppeteering’. Puppeteering is a metaphor for how a researcher-activist resonates and catalyses both the voices (ventriloquism) and actions (marionetting) of a marginalized community. Two questions and continuums are central to the framework. First, who and where the puppeteer is (insider and outsider agents). Second, what puppeteering is (action and research; radical and managerial). Examples from climate change and health research provide illustrations and contextualizations throughout. A key complication for applying PAR to address the health impacts of climate change is that for marginalized communities, climate change typically remains a few layers removed from the determinants of health. The community’s priorities may be at odds with a research and action agenda framed in terms of climate change and health.publishedVersio

Lihavuuskirurginen potilas päivystyksessä - mitä päivystäjän pitää osata epäillä?

Teema : lihavuuskirurgia. English summar

Examining relational social ontologies of disaster resilience : lived experiences from India, Indonesia, Nepal, Chile and Andean territories

Purpose The neoliberal resilience discourse and its critiques both contribute to its hegemony, obscuring alternative discourses in the context of risk and uncertainties. Drawing from the "ontology of potentiality", the authors suggest reclaiming "resilience" through situated accounts of the connected and relational every day from the global south. To explore alternate possibilities, the authors draw attention to the social ontology of disaster resilience that foregrounds relationality, intersectionality and situated knowledge. Design/methodology/approach Quilting together the field work experiences in India, Indonesia, Nepal, Chile and Andean territories, the authors interrogate the social ontologies and politics of resilience in disaster studies in these contexts through six vignettes. Quilting, as a research methodology, weaves together various individual fragments involving their specific materialities, situated knowledge, layered temporalities, affects and memories. The authors' six vignettes discuss the use, politicisation and resistance to resilience in the aftermath of disasters. Findings While the pieces do not try to bring out a single "truth", the authors argue that firstly, the vignettes provide non-Western conceptualisations of resilience, and attempts to provincialise externally imposed notions of resilience. Secondly, they draw attention to social ontology of resilience as the examples underscores the intersubjectivity of disaster experiences, the relational reaching out to communities and significant others. Originality/value Drawing from in-depth research conducted in six disaster contexts by seven scholars from South Asia, South America and Northern Europe, the authors embrace pluralist situated knowledge, and cross-cultural/language co-authoring. Thus, the co-authored piece contributes to diversifying disaster studies scholarship methodologically.Peer reviewe

Think global, act local: using a translocal approach to understand community-based organisations’ responses to planetary health crises during COVID-19

Little is known on how community-based responses to planetary health crises, such as the COVID-19 pandemic, can integrate concerns about livelihoods, equity, health, wellbeing, and the environment. We used a translocal learning approach to co-develop insights on community-based responses to complex health and environmental and economic crises with leaders from five organisations working with communities at the front line of intersecting planetary health challenges in Finland, India, Kenya, Peru, and the USA. Translocal learning supports collective knowledge production across different localities in ways that value local perspectives but transcend national boundaries. There were three main findings from the translocal learning process. First, thanks to their proximity to the communities they served, community-based organisations (CBOs) can quickly identify the ways in which COVID-19 might worsen existing social and health inequities. Second, localised CBO actions are key to supporting communities with unique challenges in the face of systemic planetary health crises. Third, CBOs can develop rights-based, ecologically-minded actions responding to local priorities and mobilising available resources. Our findings show how solutions to planetary health might come from small-scale community initiatives that are well connected within and across contexts. Locally-focused globally-aware actions should be harnessed through greater recognition, funding, and networking opportunities. Globally, planetary health initiatives should be supported by applying the principles of subsidiarity and translocalism

OSBP-related protein-2 (ORP2) : a novel Akt effector that controls cellular energy metabolism

ORP2 is a ubiquitously expressed OSBP-related protein previously implicated in endoplasmic reticulum (ER)lipid droplet (LD) contacts, triacylglycerol (TG) metabolism, cholesterol transport, adrenocortical steroidogenesis, and actin-dependent cell dynamics. Here, we characterize the role of ORP2 in carbohydrate and lipid metabolism by employing ORP2-knockout (KO) hepatoma cells (HuH7) generated by CRISPR-Cas9 gene editing. The ORP2-KO and control HuH7 cells were subjected to RNA sequencing, analyses of Akt signaling, carbohydrate and TG metabolism, the extracellular acidification rate, and the lipidome, as well as to transmission electron microscopy. The loss of ORP2 resulted in a marked reduction of active phosphorylated Akt(Ser473) and its target Glycogen synthase kinase 3(Ser9), consistent with defective Akt signaling. ORP2 was found to form a physical complex with the key controllers of Akt activity, Cdc37, and Hsp90, and to co-localize with Cdc37 and active Akt(Ser473) at lamellipodial plasma membrane regions, in addition to the previously reported ER-LD localization. ORP2-KO reduced glucose uptake, glycogen synthesis, glycolysis, mRNA-encoding glycolytic enzymes, and SREBP-1 target gene expression, and led to defective TG synthesis and storage. ORP2-KO did not reduce but rather increased ER-LD contacts under basal culture conditions and interfered with their expansion upon fatty acid loading. Together with our recently published work (Kentala et al. in FASEB J 32:1281-1295, 2018), this study identifies ORP2 as a new regulatory nexus of Akt signaling, cellular energy metabolism, actin cytoskeletal function, cell migration, and proliferation.Peer reviewe

OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism

ORP2 is a ubiquitously expressed OSBP-related protein previously implicated in endoplasmic reticulum (ER)—lipid droplet (LD) contacts, triacylglycerol (TG) metabolism, cholesterol transport, adrenocortical steroidogenesis, and actin-dependent cell dynamics. Here, we characterize the role of ORP2 in carbohydrate and lipid metabolism by employing ORP2-knockout (KO) hepatoma cells (HuH7) generated by CRISPR-Cas9 gene editing. The ORP2-KO and control HuH7 cells were subjected to RNA sequencing, analyses of Akt signaling, carbohydrate and TG metabolism, the extracellular acidification rate, and the lipidome, as well as to transmission electron microscopy. The loss of ORP2 resulted in a marked reduction of active phosphorylated Akt(Ser473) and its target Glycogen synthase kinase 3β(Ser9), consistent with defective Akt signaling. ORP2 was found to form a physical complex with the key controllers of Akt activity, Cdc37, and Hsp90, and to co-localize with Cdc37 and active Akt(Ser473) at lamellipodial plasma membrane regions, in addition to the previously reported ER–LD localization. ORP2-KO reduced glucose uptake, glycogen synthesis, glycolysis, mRNA-encoding glycolytic enzymes, and SREBP-1 target gene expression, and led to defective TG synthesis and storage. ORP2-KO did not reduce but rather increased ER–LD contacts under basal culture conditions and interfered with their expansion upon fatty acid loading. Together with our recently published work (Kentala et al. in FASEB J 32:1281–1295, 2018), this study identifies ORP2 as a new regulatory nexus of Akt signaling, cellular energy metabolism, actin cytoskeletal function, cell migration, and proliferation

Katastrofien hallinnointia kaupungistuneilla ja epätasa-arvoisilla alueilla: resilienssi ja oikeudet

Väitöstilaisuuden Lectio Praecursoria Hanken School of Economics 8.5.202

Urban Disaster Governance: Resilience and Rights in the Unequal City

While a hazard, such as an earthquake, may result from natural processes, the unequal ways in which it impacts people’s lives are not an outcome dictated by forces of nature. Indeed, the disaster unfolding from a hazard has much to do with how human societies are governed. In a disaster, marginalised people are more likely than others to lose their homes, livelihoods, lives, and people they care about. Meanwhile, powerful actors are likely able to protect themselves from many negative consequences of hazards and disasters, while sometimes even being able to capture potential benefits. These inequalities become exposed in the case of urban disasters, where people living in neighbouring residential areas may experience very different outcomes from a disaster. Addressing these inequalities calls for scrutiny on disaster governance, and the ways in which diverse actors address and experience disaster impacts. This thesis explores how disasters in the unequal city are governed, particularly within the frame of resilience discourse. Furthermore, the work strives to imagine more just urban disaster governance focused on the rights of people. The analysis is focused on elaborating and explicating the conceptualisations of resilience and rights within academic and expert literatures. The focus is on the critical analysis of bodies of knowledge on disaster governance. The thesis draws from and contributes to the interdisciplinary fields of disaster studies and human geography. The key contributions of the thesis lie in its four essays, which adopt diverse perspectives to disaster governance research and policy. A key emerging theme is the framing of subjectivities of disaster-affected people within disaster studies. Three subjectivity categories are identified: the beneficiary-stakeholder that is steered by actors ‘from above’; the active citizen that has agency only in relation to a pre-existing and persisting governance institutions; and the territorial community that is a political and organised group of people that can assert claims. In addition to these subjectivity categories, a broader narrative emerges in the thesis: one where a diffused network of private and non-state actors increasingly has the resources and power to shape how the exception of disasters is framed and governed. Against this backdrop, conceptualisations (e.g. resilient community), discourses (e.g. urban resilience) and streams of literature that may be benign in and of themselves may shape disaster politics in problematic ways. They might decentre and obscure underlying patterns of marginalisation and facilitation that result in unequal disaster risk – at worst delegitimising the politics that target structural causes of disasters